Yoghurt Prozac

Prozac in the yoghurt aisle?

The idea that fermented foods — including yoghurt and kefir — are good for us goes way back. But could the benefits of “good bacteria” extend beyond our guts to our brains?

Nobel Prize-winning scientist Elie Metchnikoff (also known as Ilya Ilich Mechnikov) first observed a connection between fermented milk and longevity among Bulgarian peasants more than a century ago.

“Metchnikoff is regarded by many as the father of probiotics,” says Gregor Reid of the University of Western Ontario, who published a look back at Metchnikoff’s contributions.

Metchnikoff came up with “the scientific rationale for the use of live microbes in the prevention and treatment of infections,” according to Reid. And back in 1907, he says, Metchnikoff hypothesised that replacing or diminishing the number of bad bacteria in the gut with lactic acid bacteria — like the kind found in yoghurt and kefir — “could normalise bowel health and prolong life.”

But Metchnikoff’s ideas were ignored for decades. Reid says after the discovery of penicillin, science focused on the use of antibiotics to kill off harmful bacteria.

It’s only recently, Reid says, that the importance of beneficial bacteria has come into the limelight.

More than a century ago, Elie Metchnikoff, a Nobel Prize-winning microbiologist, hypothesised that lactic acid bacteria — like the kind found in yoghurt — was important to gut health and longevity.

“Bacteria used to be the thing we had to eradicate,” Reid says. But people are now realising that many kinds of bacteria provide a benefit. “So it’s a paradigm shift, a massive shift in our thinking,” he says.

This shift has led to an explosive growth in research. Scientists have documented that beneficial microorganisms play a critical role in how our bodies function. And along the way, it’s become clear that the influence goes beyond the gut. Scientists have documented that the mix of bacteria that populate our gut influence our susceptibility to — or our immunity against — allergies, eczema and asthma.

Now, researchers are turning their attention to our emotional health. It turns out that there’s a lot of communication between our guts and our brains. Scientists studying this refer to it as the gut-brain axis.

“The gut-brain axis is the collective communication pathway between the gastrointestinal tract and the brain,” explains John Cryan, a professor of anatomy and neuroscience at University College Cork in Ireland.

Some of the information travels along the vagus nerve, which extends from our guts to our brains. Cryan says the idea that the two regions are so interconnected should not be a surprise.

“Think of phrases in our everyday language,” Cryan says. We have “gut instincts” and “gut feelings,” he notes — or if we’re brave, then we’re “gutsy.”

“We refer to butterflies in our tummy if we’re feeling a bit anxious. So we portray a raft of human emotions directly in our gut,” he says.

A few years back, Cryan and his colleagues published the findings of a simple experiment. They took a strain of lactobacillus — known as Lactobacillus rhamnosus — that’s one of the most commonly used probiotics, or beneficial microorganisms.

They fed it to one group of mice every day for a month, and they looked to see if the rodents’ behavior changed. The results, Cryan says, were striking.

“What we found was that the animals that were fed the lactobacillus — compared to those that were just fed a regular broth — were a lot less anxious. And they behaved almost as if they were on Valium or Prozac,” he says.

Other labs doing similar animal experiments have also shown that probiotics can influence their emotional state.

But, of course, mice are not people. For starters, their emotional lives are much less complicated.

So researchers have begun to explore whether this effect may be seen in humans. To date, there have been a handful of small studies.

Take, for instance, a recent study published in the journal Brain, Behavior, and Immunity…..

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